Dr Tuuli Lappalainen’s research group studies functional genetic variation in the human populations. We are particularly interested in characterizing how genetic variants affect the transcriptome, and how these cellular changes contribute to genetic risk for both common and rare diseases and traits. We analyze these questions both by computational integration analysis of large genomic and transcriptomic data sets and by experimental approaches.

The lab is part of the New York Genome Center where we are physically located, and affiliated also to the Department of Systems Biology at Columbia University.