Professor Tuuli Lappalainen’s research group studies functional genetic variation in the human populations. We are particularly interested in characterizing how genetic variants affect the transcriptome, and how these cellular changes contribute to genetic risk for both common and rare diseases and traits. We analyze these questions both by computational integration analysis of large genomic and transcriptomic data sets and by experimental approaches.
The lab is based at the New York Genome Center in New York City, USA, and at KTH Royal Institute of Technology and SciLifeLab in Stockholm, Sweden. We also interact with the Department of Systems Biology at Columbia University.